Efficacy and Safety of Cold-Induced Noninvasive Targeted Fat Reduction in Pseudogynecomastia

초록

Background: Treatment options for pseudogynecomastia are limited, and the demand fornoninvasive breast fat reduction is increasing. Objective: We evaluated the efficacy and safety of a cold-induced lipolysis device for treatingpseudogynecomastia. Methods: In this 16-week prospective trial, a total of 15 male patients with pseudogyne-comastia were treated twice with cryolipolysis. The primary endpoint was a change in thechest circumference from baseline at posttreatment week 8. Secondary endpoints werechanges in body weight, fat thickness assessed using ultrasonography, independent evalua-tor- and patient-rated improvement, and Simon’s gynecomastia class (SGC) grading. Results: The primary assessment, a reduction of 3.05 cm in the mean chest circumference at8 weeks post-treatment compared to baseline, was statistically significant. The treatment ef-fect was cumulative, with a steady decrease in chest circumference and fat thickness over the16-week study period. The mean pain score immediately after the first session of treatmentwas 2.0±1.36, based on a scale of 0~10, with a score of 10 being the worst pain ever experi-enced. The pain decreased substantially after the end of the procedure. Conclusion: Cryolipolysis was demonstrated to be an effective and safe option for reducingbreast fat in pseudogynecomastia. Male with mild to moderate breast enlargement withoutskin excess can be ideal candidates.

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