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Simple and Efficient Enantioselective α-Deuteration Method of α-Amino Acids without External Chiral Sources
- Park, Soojun;
- Kim, Jae Hyun;
- Kim, Dongjun;
- Kim, Yeonjoon;
- Kim, Seonah;
- 외 1명
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3초록
Deuterium-labeled α-amino acids are useful in research related to drug discovery and biomedical science. However, a high degree of site selectivity and stereoselectivity in the deuterium incorporation process is still difficult to achieve. Herein, we report a new enantioselective deuteration method at the α-position of several amino acids without external chiral sources. The proposed deuteration methods (NaOEt and EtOD) are highly selective and simple. Additionally, we provide a mechanistic study for this enantioretentive deuteration.
키워드
enantioretentive; memory of chirality; α-amino acids; α-deuterated amino acids; α-deuteration; MEMORY; ACTIVATION; MECHANISMS; STATE
- 제목
- Simple and Efficient Enantioselective α-Deuteration Method of α-Amino Acids without External Chiral Sources
- 저자
- Park, Soojun; Kim, Jae Hyun; Kim, Dongjun; Kim, Yeonjoon; Kim, Seonah; Kim, Sanghee
- 발행일
- 2024-05
- 유형
- Article; Early Access
- 저널명
- JACS Au
- 권
- 4
- 호
- 6
- 페이지
- 2246 ~ 2251