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ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
- Kim, Kyeongha;
- Kim, Hun Young;
- Oh, Kyungsoo
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15초록
A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-freeortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra (TM)) in a highly convergent manner.
키워드
ONE-POT SYNTHESIS; O-AMINOBENZAMIDES; CASCADE SYNTHESIS; N-HETEROCYCLES; DOMINO SYNTHESIS; AQUEOUS AMMONIA; BENZYL ALCOHOLS; LUOTONIN-B; QUINAZOLINONES; QUINAZOLIN-4(3H)-ONES
- 제목
- ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
- 저자
- Kim, Kyeongha; Kim, Hun Young; Oh, Kyungsoo
- 발행일
- 2020-08
- 유형
- Article
- 저널명
- RSC Advances
- 권
- 10
- 호
- 52
- 페이지
- 31101 ~ 31105
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- 분량
- 5 페이지
- ISSN
- E 2046-2069