ScholarWorks@중앙대학교

초록

Zika virus, a mosquito-borne virus, is associated with congenital birth defects and neurologicalcomplications. However, despite its significant public health threat, no approved vaccinesor antiviral treatments are currently available. Therefore, this study aims to identify kinesinfamily member 20A as a key host factor promoting Zika virus life cycle. The elevated expressionof kinesin family member 20A following Zika virus infection suggests its role in the virallife cycle. Suppressing its expression through gene silencing or inhibiting its function with asmall-molecule inhibitor significantly reduced viral infectivity in host cells. Furthermore, kinesinfamily member 20A is essential for facilitating viral internalization, a key step in the entrystep. These findings suggest its significance in the Zika virus life cycle and highlight itspotential as a novel therapeutic target for the Zika virus.

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