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The Mycobacterium avium subsp Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4
- Lee, Su Jung;
- Noh, Kyung Tae;
- Kang, Tae Heung;
- Han, Hee Dong;
- Shin, Sung Jae;
- ... Shin, Yong Kyoo;
- 외 7명
WEB OF SCIENCE
14SCOPUS
15초록
In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-alpha, and IL-1 beta) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized CD4(+) and CD8(+) T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of CD4(+) and CD8(+) T cells.
키워드
- 제목
- The Mycobacterium avium subsp Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4
- 저자
- Lee, Su Jung; Noh, Kyung Tae; Kang, Tae Heung; Han, Hee Dong; Shin, Sung Jae; Soh, Byoung Yul; Park, Jung Hee; Shin, Yong Kyoo; Kim, Han Wool; Yun, Cheol-Heui; Park, Won Sun; Jung, In Duk; Park, Yeong-Min
- 발행일
- 2014-02
- 유형
- Article
- 저널명
- BMB Reports
- 권
- 47
- 호
- 2
- 페이지
- 115 ~ 120
- 언어
- ENG
- 출판사
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1976-670X
P 1976-6696