Cellular organelle-based renal toxicity

초록

It is generally agreed that mitochondria play a key role in the regulation of apoptosis (1). Mitochondrial cell death is characterized by the permeabilization of the outer mitochondrial membrane (OMM), which leads to the release of apoptogenic proteins from the mitochondrial inner membrane into the cytosol and these proteins leads to the subsequent activation of caspase cascade and the cleavage of multiple intracellular substrates. © 2014 by Taylor & Francis Group, LLC.