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Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
- Kim, Jeongmi;
- Park, Minji;
- Do, Eunsoo;
- Jung, Won Hee
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5초록
Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.
키워드
Cryptococcus neoformans; Fe-S cluster; Metals; Mitochondria; Nfu1; AZOTOBACTER-VINELANDII; SACCHAROMYCES-CEREVISIAE; IRON; METABOLISM; VIRULENCE; CLUSTER; IDENTIFICATION; BIOSYNTHESIS; NITROGENASE; MATURATION
- 제목
- Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
- 저자
- Kim, Jeongmi; Park, Minji; Do, Eunsoo; Jung, Won Hee
- 발행일
- 2014-12
- 유형
- Article
- 저널명
- Mycobiology
- 권
- 42
- 호
- 4
- 페이지
- 427 ~ 431
- 언어
- ENG
- 출판사
- KOREAN SOC MYCOLOGY
- 발행국가
- 대한민국
- 분량
- 5 페이지
- ISSN
- E 2092-9323
P 1229-8093