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The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
- Seo, J.;
- Ha, J.;
- Kang, E.;
- Cho, S.
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77초록
The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs.
키워드
Drug resistance; Epithelial-mesenchymal transition; Snail; Transcription factor; Twist1; ZEB1; BREAST-CANCER CELLS; RECEPTOR TYROSINE KINASE; UP-REGULATION; MULTIDRUG-RESISTANCE; CISPLATIN RESISTANCE; MOLECULAR-MECHANISMS; GENE-EXPRESSION; BLADDER-CANCER; ZYGOTIC GENE; STEM-CELLS
- 제목
- The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
- 저자
- Seo, J.; Ha, J.; Kang, E.; Cho, S.
- 발행일
- 2021-03
- 유형
- Review
- 권
- 44
- 호
- 3
- 페이지
- 281 ~ 292
- 언어
- ENG
- 출판사
- Pharmaceutical Society of Korea
- 발행국가
- 대한민국
- 분량
- 12 페이지
- ISSN
- E 1976-3786
P 0253-6269