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Specialised ribosomes as versatile regulators of gene expression
- Joo, Minju;
- Yeom, Ji-Hyun;
- Choi, Younkyung;
- Jun, Hyeon;
- Song, Wooseok;
- ... Lee, Kangseok;
- 외 2명
Citations
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20Citations
SCOPUS
18초록
The ribosome has long been thought to be a homogeneous cellular machine that constitutively and globally synthesises proteins from mRNA. However, recent studies have revealed that ribosomes are highly heterogeneous, dynamic macromolecular complexes with specialised roles in translational regulation in many organisms across the kingdoms. In this review, we summarise the current understanding of ribosome heterogeneity and the specialised functions of heterogeneous ribosomes. We also discuss specialised translation systems that utilise orthogonal ribosomes. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
키워드
divergent rRNA; orthogonal ribosome; post-translational modification; ribosomal protein; ribosome heterogeneity; Specialised ribosome; UNNATURAL AMINO-ACIDS; ESCHERICHIA-COLI; MESSENGER-RNA; PROTEIN-SYNTHESIS; POSTTRANSLATIONAL MODIFICATIONS; DEVELOPMENTAL REGULATION; ORTHOGONAL TRANSLATION; HALOARCULA-MARISMORTUI; STRUCTURALLY DISTINCT; CONCERTED EVOLUTION
- 제목
- Specialised ribosomes as versatile regulators of gene expression
- 저자
- Joo, Minju; Yeom, Ji-Hyun; Choi, Younkyung; Jun, Hyeon; Song, Wooseok; Kim, Hyun-Lee; Lee, Kangseok; Shin, Eunkyoung
- 발행일
- 2022-12
- 유형
- Review
- 저널명
- RNA Biology
- 권
- 19
- 호
- 1
- 페이지
- 1103 ~ 1114
- 언어
- ENG
- 출판사
- Taylor and Francis Ltd.
- 발행국가
- 미국
- 분량
- 12 페이지
- ISSN
- E 1555-8584
P 1547-6286