사람태아 간적혈구형성에 따른 간세포의 변화

초록

The ultrastructural development of fetal liver cells according to the activity of hepatic erythropoiesis was studied with 15 human fetal livers from 7 to 34 weeks of gestation. 1) The 1st stage(7-8 weeks of gestation) : The nucleus of hepatocyte was oval with granular euchromatin evenly dispersed throughout the interior and prominent nucleoli. The hepatocytes often exhibited many mitochondria and short dilated rERs but no sERs and glycogen deposit. Two types of reticulum cells with intracellular organelles developed with close relation with erythropoietic cells. The nucleus of the 1st type was similar with that of hepatocyte and the cytoplasm was full of well-developed multilayered rERs and numerous mitochondria. The nucleus of the 2nd type was irregular and has high electron-dense nucleoplasm and the cytoplasm was packed with more developed multilayered rERs and oval mitochondria. 2) The 2nd stage(9-22 weeks of gestation) : Most of hepatocytes differentiated well and exhibited numerous mitochondria and free ribosome, 5 to 6 layered rER, glycogen deposit and there were appearance of sER and hemosiderin in the cytoplasm. With age, the 2nd type reticulum cell became the majority and had more glycogen deposit and less rER. The space of Disse was well-developed but the sinusoidal wall was still immature. 3) The 3rd stage(23-34 weeks of gestation) : The majority of hepatocytes were mature cells. Reticulum cells, greatly decreasing with age, exhibited increasing lipid storage and decrease of mitochondria and rER. In summary, the maturation of hepatocyte and activity of reticulum cell may influence the hepatic erythropoiesis.