ScholarWorks@중앙대학교

초록

Purpose The objective of this nationwide population-based cohort study was to determine the association between habitual alcohol consumption and the incidence of newly diagnosed obstructive sleep apnea (OSA). Methods This study used data from the Korean National Health Insurance Service database and included individuals aged ≥ 40 years who underwent a health check-up in 2011 or 2012. Individuals with a prior history of sleep apnea were excluded. Habitual alcohol consumption was defined as a weekly alcohol intake greater than 0 g. The study outcome was the newly identified cases of OSA, which we evaluated using the Cox proportional hazards regression model. Results A total of 3,988,993 individuals (mean age, 54.5 years; male, 50.1%; mean body mass index [BMI], 24.0 kg/m²) were included, of whom 1,688,094 (42.3%) had habitual alcohol consumption. During a mean follow-up period of 9.7 years, 33,563 new cases of OSA were documented. Individuals with habitual alcohol consumption had an incidence rate of 108.9 per 100,000 person-years, whereas those without habitual alcohol consumption had a rate of 69.6 per 100,000 person-years. Following adjustment for covariates including age, sex, BMI, income, smoking status, physical activity, and the Charlson comorbidity index, the hazard ratio for incident OSA was 1.026 (95% confidence interval, 1.001–1.051). The association between habitual alcohol consumption and incident OSA was more prominent among males and those with underlying chronic kidney disease or a history of cancer. Conclusion This large-scale Korean population-based cohort study revealed that habitual alcohol consumption is associated with an increased incidence of OSA.

키워드