사람 태아 신장의 신사구체의 분화

초록

The differentiation of foot processes, filtration slits and basal laminae in the developing glomeruli of 20-human fetal kidneys was studied electronmicroscopically. The lamina densa of basal lamina between the immature epithelium and the capillary endothelium was faint and thin, but with differentiation it became thicker and denser. The basal laminae composed of double thin laminae densa were occasionally observed, which suggests that the glomerular basal lamina is a product of endothelial and visceral epithelial cells. The flow phenomenon of the zonular occludens from the apex to the basal lamina was observed apparently between the visceral epithelial cells at the stages before the late developing capillary loop. After the movement of the zonular occludensnear basal lamina, the foot processes began to appear with broad bases and the interdigitations increased with differentiation. The electron density of visceral epithelial cells was higher at the foot processes and near the basal laminae. With the movenent near the basal lamina, the zonular occludens was transformed into fasciae occludens or maculae occludens which eventually disappeared. And finally the slit diaphragms appeared between the foot processes in the mature glomeruli.

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