iSERS Bioassays

초록

During the past three decades, there has been a growing interest in the biological applications of SERS spectroscopy. In this chapter, recent advances in SERS-based bioanalytical techniques have been introduced. A combination of SERS detection techniques with various microdevices, including suspension arrays, gold-patterned microarrays, LFA strips, and microfluidic platforms, provides a highly sensitive and reproducible sensing tools for bioassays. This SERS-based bioassay platform successfully detected a series of bioanalytes, including cancer cells, bacteria, viruses, pathogens, biomarker antigens, and genes. In many cases, the SERS-based bioassay techniques overcome some of the problems in conventional bioassays, such as low sensitivity and inability of multiplex detection. We believe the SERS-based assay platform will be powerful analytical tools for bioanalysis and disease diagnostics. © 2022 World Scientific Publishing Company.