Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial

초록

Observational studies have linked lower levels of omega-3 (. n-3) polyunsaturated fatty acids (PUFAs) with inflammation and depression. This study was designed to determine whether . n-3 supplementation would decrease serum cytokine production and depressive symptoms in 138 healthy middle-aged and older adults (average age. =. 51.04, SD. =. 7.76) who were sedentary and overweight (average BMI. =. 30.59, SD. =. 4.50). This three-arm randomized, placebo-controlled, double-blind 4-month trial compared responses to (1) 2.5. g/d . n-3 PUFAs, or (2) 1.25. g/d . n-3 PUFAs, or (3) placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Serum interleukin-6 decreased by 10% and 12% in our low and high dose . n-3 groups, respectively, compared to a 36% increase in the placebo group. Similarly, low and high dose . n-3 groups showed modest 0.2% and -2.3% changes in serum tumor necrosis factor alpha, compared to a 12% increase in the control group. Depressive symptoms were quite low at baseline and did not change significantly in response to supplementation. Our data suggest that . n-3 PUFAs can reduce inflammation in overweight, sedentary middle-aged and older adults, and thus could have broad health benefits. These data provide a window into the ways in which the . n-3 PUFAs may impact disease initiation, progression, and resolution.ClinicalTrials.gov identifier: . NCT00385723. © 2012 Elsevier Inc.

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