Dual-Level Biomemory Device Composed of Cytochrome c/DNA/Myoglobin Heterolayer

초록

In this study, heterolayer composed of cytochrome c/DNA/myoglobin is fabricated for the demonstration of dual-level biomemory device. Metalloprotein and single stranded DNA are conjugated via chemical linkage, and then two different kinds of conjugates are connected by DNA hybridization which can provide stable and selective combination to form heterolayer on gold substrate. To verify the conjugation of metalloprotein and single stranded DNA, sodium dodecyl sulfate polyacrylamide gel electrophoresis and ultraviolet-visible spectroscopy are used. Morphological change by the heterolayer formation is investigated by atomic force microscopy. Cyclic voltammetry is used to investigate the electrochemical property of heterolayer. Dual-level memory functions are achieved by multi-potential step chronoamperometry. From results, heterolayer is well fabricated by DNA hybridization, and dual-level memory functions are well demonstrated with improved memory density. The proposed dual-level biomemory device can provide new approaching method to fabricate bioelectronic devices with high selectivity and functionality.

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