상세 보기
Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs
- Jung, Kyoung Ho;
- Lee, So Yeon;
- Park, So Eun;
- Kang, Young Woo;
- Park, Hyun Ho
Citations
WEB OF SCIENCE
2Citations
SCOPUS
2초록
LabB (YciM) is a key regulator of lipopolysaccharide (LPS) biosynthesis in Gram-negative bacteria, modulating LpxC degradation to maintain outer membrane integrity. While E. coli LabB (ecLabB) forms a closed-ring dimer via TPR motifs, the crystal structure of Klebsiella pneumoniae LabB (kpLabB) reveals a distinct open-ring dimeric architecture, generated by TPR motif sliding. This alternative conformation suggests a potential mechanism for dynamic regulation and partner interactions.
키워드
Crystal structure; Klebsiella pneumoniae; LPS synthesis; LabB; Superbugs; LIPOPOLYSACCHARIDE; LAPB
- 제목
- Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs
- 저자
- Jung, Kyoung Ho; Lee, So Yeon; Park, So Eun; Kang, Young Woo; Park, Hyun Ho
- 발행일
- 2025-08
- 유형
- Article
- 권
- 775