Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs

Jung, Kyoung Ho; Lee, So Yeon; Park, So Eun; Kang, Young Woo; Park, Hyun Ho

doi:10.1016/j.bbrc.2025.152151

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Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs

Jung, Kyoung Ho;
Lee, So Yeon;
Park, So Eun;
Kang, Young Woo;
Park, Hyun Ho

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초록

LabB (YciM) is a key regulator of lipopolysaccharide (LPS) biosynthesis in Gram-negative bacteria, modulating LpxC degradation to maintain outer membrane integrity. While E. coli LabB (ecLabB) forms a closed-ring dimer via TPR motifs, the crystal structure of Klebsiella pneumoniae LabB (kpLabB) reveals a distinct open-ring dimeric architecture, generated by TPR motif sliding. This alternative conformation suggests a potential mechanism for dynamic regulation and partner interactions.

키워드

Crystal structure; Klebsiella pneumoniae; LPS synthesis; LabB; Superbugs; LIPOPOLYSACCHARIDE; LAPB

제목: Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs

저자: Jung, Kyoung Ho; Lee, So Yeon; Park, So Eun; Kang, Young Woo; Park, Hyun Ho

DOI: 10.1016/j.bbrc.2025.152151

발행일: 2025-08

유형: Article

저널명: Biochemical and Biophysical Research Communications

권: 775

언어: ENG

출판사: Elsevier B.V.

발행국가: 미국

ISSN: E 1090-2104
P 0006-291X