ScholarWorks@중앙대학교

초록

As the aging population grows, increasing interest in promoting healthy aging through dietary interventions is growing. Gut microbiota play a key role in age-related physiological decline and longevity. We investigated whether lignan-enriched nutmeg extract (LNX) could modulate the gut microbiota of aged mice. C57BL/6 mice (27 months old) were orally administered LNX for 5 weeks and compared to young (3 months) and aged controls. LNX significantly reduced body weight without affecting food intake. 16S rRNA sequencing showed that age-related microbial shifts, including decreased Firmicutes and increased Bacteroidota, were partially reversed by LNX. While microbial diversity was unchanged, LNX increased Bifidobacterium, Blautia, and Acetatifactor muris, a taxon previously associated with healthy aging, and reduced Turicibacter sanguinis, linked to normal aging. These findings suggest that LNX modulates specific microbial taxa without broadly restoring a youthful microbiota composition. © 2025 The Authors

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