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Insight of current technologies for oral delivery of proteins and peptides
- Chin, J.;
- Foyez, Mahmud K.A.;
- Kim, S.E.;
- Park, K.;
- Byun, Y.
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28초록
Although significant progress has been made in developing oral formulations to deliver bioactive proteins and peptide therapeutics, oral routes still need to overcome formidable barriers such as poor stability and permeability and rapid enzymatic degradation. Thus, novel formulation technologies for oral delivery of proteins and peptides are needed to further improve the bioavailability and therapeutic efficacy. In recent decades, researchers have attempted different strategies to successfully deliver proteins orally. In this review, we examine the current technologies being developed for protein and peptide oral delivery. © 2012 Elsevier Ltd. All rights reserved.
키워드
calcitonin; human growth hormone; human insulin; hybrid protein; insulin; liposome; metformin; nanocarrier; parathyroid hormone[1-34]; peptides and proteins; pioglitazone; recombinant human insulin; recombinant parathyroid hormone; sulfonylurea derivative; article; cell engineering; cross linking; crystallization; drug absorption; drug delivery system; drug formulation; drug transport; enzymatic degradation; human; liposomal delivery; microemulsion; molecular library; mucoadhesion; non insulin dependent diabetes mellitus; nonhuman; tablet formulation
- 제목
- Insight of current technologies for oral delivery of proteins and peptides
- 저자
- Chin, J.; Foyez, Mahmud K.A.; Kim, S.E.; Park, K.; Byun, Y.
- 발행일
- 2012
- 유형
- Review
- 권
- 9
- 호
- 2
- 페이지
- e105 ~ e112
- 언어
- ENG
- 출판사
- Elsevier Ltd
- 발행국가
- 네덜란드
- ISSN
- P 1740-6749