Synthesis and anti-platelet activity of obovatol derivatives

Kwak, Jae-Hwan; Lee, Seul; Park, Eun-Seok; In, Jin-Kyung; Song, Jiho; Kim, Young Jin; Choi, Nam Song; Lee, Heesoon; Yun, Yeo-Pyo; Hong, Jin Tae; Kwak, Young-Shin; Min, Kyung Hoon; Jung, Jae-Kyung

doi:10.1007/s12272-011-0708-9

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Synthesis and anti-platelet activity of obovatol derivatives

Kwak, Jae-Hwan;
Lee, Seul;
Park, Eun-Seok;
In, Jin-Kyung;
Song, Jiho;
... Min, Kyung Hoon;
외 7명

Citations

WEB OF SCIENCE

6

Citations

SCOPUS

8

초록

Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.

키워드

Obovatol; Anti-platelet activity; Derivatives; Small molecules; COLLAGEN; CALCIUM; ACID

제목: Synthesis and anti-platelet activity of obovatol derivatives

저자: Kwak, Jae-Hwan; Lee, Seul; Park, Eun-Seok; In, Jin-Kyung; Song, Jiho; Kim, Young Jin; Choi, Nam Song; Lee, Heesoon; Yun, Yeo-Pyo; Hong, Jin Tae; Kwak, Young-Shin; Min, Kyung Hoon; Jung, Jae-Kyung

DOI: 10.1007/s12272-011-0708-9

발행일: 2011-07

유형: Article

저널명: Archives of Pharmacal Research

권: 34

호: 7

페이지: 1107 ~ 1112

언어: ENG

출판사: PHARMACEUTICAL SOC KOREA

발행국가: 대한민국

분량: 6 페이지

ISSN: E 1976-3786
P 0253-6269