Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique

Han, J.-H.; Lee, Y.Y.; Shin, H.E.; Han, J.; Kang, J.M.; James, Wang C.-P.; Park, J.-H.; Kim, S.-N.; Yoon, J.-H.; Kwon, H.-K.; Park, D.-H.; Park, T.-E.; Choy, Y.B.; Kim, D.-H.; Kim, Tae-Hyung; Min, Jun Hong; Kim, I.-H.; Park, C.G.; Han, D.K.; Park, W.

doi:10.1016/j.biomaterials.2022.121762

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Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique

Han, J.-H.;
Lee, Y.Y.;
Shin, H.E.;
Han, J.;
Kang, J.M.;
... Min, Jun Hong;
외 14명

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초록

Cancer immunotherapy is a next-generation treatment strategy; however, its side effects limit its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) prepared with an iron oxide/gold core and a cationic polymer shell via multilayer synthesis with CpG oligodeoxynucleotide (CpG-ODN) electrostatically complexed on its surface, and irreversible electroporation (IRE) technique was developed for effective image-guided in situ cancer vaccination. The M-NA can be retained long-term in the dense tumoral extracellular matrix after intratumoral injection and internalized by antigen-presenting cells (APCs). The IRE can induce immunogenic cell death. Indeed, in a mouse tumor model, the M-NA showed longer tumor retention time than free CpG-ODN. Compared with other treatments, the combined treatment significantly inhibited tumor growth with 100% survival rate for ∼60 days. The therapy induced the activation of cytotoxic lymphocytes and the maturation of APCs in vivo. This treatment could be effective in image-guided local cancer immunotherapy. © 2022 Elsevier Ltd

키워드

Cancer immunotherapy; Image-guided cancer therapy; Irreversible electroporation; Multi-functional nano-adjuvant; IMMUNOGENIC CELL-DEATH; CYTOKINE PRODUCTION; PHASE-I; IMMUNOTHERAPY; TUMOR; CPG; NANOPARTICLES; IPILIMUMAB; NIVOLUMAB; ABLATION

제목: Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique

저자: Han, J.-H.; Lee, Y.Y.; Shin, H.E.; Han, J.; Kang, J.M.; James, Wang C.-P.; Park, J.-H.; Kim, S.-N.; Yoon, J.-H.; Kwon, H.-K.; Park, D.-H.; Park, T.-E.; Choy, Y.B.; Kim, D.-H.; Kim, Tae-Hyung; Min, Jun Hong; Kim, I.-H.; Park, C.G.; Han, D.K.; Park, W.

DOI: 10.1016/j.biomaterials.2022.121762

발행일: 2022-10

유형: Article

저널명: Biomaterials

권: 289

언어: ENG

출판사: Elsevier Ltd

발행국가: 영국

ISSN: E 1878-5905
P 0142-9612