Trifluoromethylation of heterocycles via visible light photoredox catalysis

Iqbal, Naeem; Choi, Sungkyu; Ko, Euna; Cho, Eun Jin

doi:10.1016/j.tetlet.2012.02.032

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Trifluoromethylation of heterocycles via visible light photoredox catalysis

Iqbal, Naeem;
Choi, Sungkyu;
Ko, Euna;
Cho, Eun Jin

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WEB OF SCIENCE

193

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200

초록

A method has been developed for the visible light-induced trifluoromethylation of heterocyclic compounds. A variety of electron-rich heterocycles were transformed into trifluoromethylated products by using CF3I as the trifluoromethyl radical source and Ru(bpy)(3)Cl-2 as the photocatalyst under mild reaction conditions. This operationally simple and eco-friendly process can introduce trifluoromethyl groups without prefunctionalization. (C) 2012 Elsevier Ltd. All rights reserved.

키워드

Visible light; Photoredox catalysis; Trifluoromethylation; Heterocycles; Ruthenium; C-H FUNCTIONALIZATION; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; BORONIC ACIDS; ARYL; PHOTOCATALYSIS; FLUORINATION; BOND; CYCLOADDITIONS

제목: Trifluoromethylation of heterocycles via visible light photoredox catalysis

저자: Iqbal, Naeem; Choi, Sungkyu; Ko, Euna; Cho, Eun Jin

DOI: 10.1016/j.tetlet.2012.02.032

발행일: 2012-04

유형: Article

저널명: Tetrahedron Letters

권: 53

호: 15

페이지: 2005 ~ 2008

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: P 0040-4039