5-Hydroxytryptamine attenuates free radical injury in primary mouse cortical cultures

Kang, Youn Kang; Kang, Hyo Jung; Chung, Young Ki; Gwag, Byoung Joo; Noh, Jai Sung

doi:10.1097/00001756-200104170-00020

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5-Hydroxytryptamine attenuates free radical injury in primary mouse cortical cultures

Kang, Youn Kang;
Kang, Hyo Jung;
Chung, Young Ki;
Gwag, Byoung Joo;
Noh, Jai Sung

Citations

WEB OF SCIENCE

9

Citations

SCOPUS

8

초록

The effects of 5-hydroxytryptamine (5-HT) on several types of neuronal injury in mouse cortical cell cultures were tested. Co-treatment with 5-HT prevented free radical-mediated neuronal necrosis induced by FeCl2 or buthionine sulfoximine (BSO) in a dose-dependent manner. Subtype antagonists did not reverse the protective effect and 5-HT showed direct free radical scavenging activity evidenced by its ability to reduce the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) in a cell-free system. Excitotoxic necrosis induced by NMDA or apoptosis induced by staurosporine was not sensitive to 5-HT treatment. These features raise the possibility that the endogenous neurotransmitter 5-HT may work as an innate antioxidant defense mechanism in the CNS. NeuroReport 12:963-966 (C) 2001 Lippincott Williams & Wilkins.

키워드

aapoptosis; cortical cultures; free radicals; 5-hydroxytryptamine; necrosis; 5-HT1A RECEPTOR AGONIST; SERUM DEPRIVATION; CELL-CULTURES; IN-VITRO; NEURONS; BAY-X-3702; APOPTOSIS; NEUROTOXICITY; NECROSIS; DEATH

제목: 5-Hydroxytryptamine attenuates free radical injury in primary mouse cortical cultures

저자: Kang, Youn Kang; Kang, Hyo Jung; Chung, Young Ki; Gwag, Byoung Joo; Noh, Jai Sung

DOI: 10.1097/00001756-200104170-00020

발행일: 2001-04

유형: Article

저널명: NeuroReport

권: 12

호: 5

페이지: 963 ~ 966

언어: ENG

출판사: LIPPINCOTT WILLIAMS & WILKINS

발행국가: 미국

분량: 4 페이지

ISSN: E 1473-558X
P 0959-4965