다중 커널을 이용한 파킨슨 환자로부터 보행 동결 진행까지의 페널티 콕스 회귀 분석

초록

Objectives: The objective of this study was to investigate complex non-linear associations of multiple genetic and brain imaging factors and the interac- tions of the two factors with the risk of gait freezing for patients with Parkinson’s disease (PD). Methods: We employed a penalized kernel machine Cox proportional hazard regression model. Multiple kernels were created to account for multiple genetic factors and their interactions with brain imaging factors, and we identified significant elements using the group lasso penalty. We applied the proposed method to Parkinson’s Progression Markers Initia- tive (PPMI) data. Results: We identified LRRK2 genes and the volume of six regions of interest in brain interacting with COMT, GBA, LRRK2, and SNCA genes that are associated with the occurrence of freezing of gait for PD patients. Conclusions: It was found that there is evidence of gene-brain interac- tions in freezing of gait. The proposed penalized Cox model using the kernel machine method enables us to identify the nonlinear relationship between genetic and neuroimaging factors and the occurrence of neurodegenerative diseases.

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