Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

초록

Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a single-center, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

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