상세 보기
New Insights into IGF-1 Signaling in the Heart
- Lee, Wang-Soo;
- Abel, E Dale;
- Kim, Jaetaek
Citations
WEB OF SCIENCE
14Citations
SCOPUS
17초록
Insulin-like growth factor (IGF)-1 signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart disease and contributes to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging and remodeling.
키워드
IGF-1; cardiac aging; electrical remodeling; fibrosis; heart failure; GROWTH-FACTOR-I; ISCHEMIA-REPERFUSION INJURY; FACTOR-BINDING PROTEIN-7; INSULIN-LIKE; ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; STEM-CELLS; DIASTOLIC DYSFUNCTION; EJECTION FRACTION; CARDIAC FIBROSIS
- 제목
- New Insights into IGF-1 Signaling in the Heart
- 저자
- Lee, Wang-Soo; Abel, E Dale; Kim, Jaetaek
- 발행일
- 2024-09
- 유형
- Review
- 저널명
- Physiology
- 권
- 39
- 호
- 5
- 페이지
- 0 ~ 312
- 언어
- ENG
- 출판사
- AMER PHYSIOLOGICAL SOC
- 발행국가
- 미국
- 분량
- 313 페이지
- ISSN
- E 1548-9221
P 1548-9213