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HPLC-UV를 이용한 중마황의 (+)-Pseudoephedrine과 (-)-Ephedrine의 동시분석법 개발
Simultaneous Determination of (+)-Pseudoephedrine and (-)-Ephedrine in Ephedra intermedia by HPLC-UV
- 정비랑;
- 윤유식;
- 신순식;
- 권용수;
- 양희정
Citations
SCOPUS
1초록
Ephedra alkaloids, (-)-ephedrine, (+)-pseudoephedrine, (-)-N-methylephedrine, (+)-N-methylpseudoephedrine, (-)- norephedrine and (+)-norpseudoephedrine, from ephedra herb are sympathomimetic agonists causing an increase of metabolism, blood pressure and perspiration. In this study, we developed the validation method of (+)-pseudoephedrine and (-)-ephedrine, two major ephedra alkaloids in Ephedra spp., by high-performance liquid chromatography-ultraviolet spectrometer (HPLC-UV). HPLC analysis was performed using a HECTOR-M C18 column operating at 35°C, and UV detection at 215nm. The mobile phase used a gradient flow with 25 mM SDS in water (A) and acetonitrile (B). © 2017, Korean Society of Pharmacognosy. All rights reserved.
키워드
Ephedra intermedia; Ephedrine; HPLC analysis; Method validation; Pseudoephedrine
- 제목
- HPLC-UV를 이용한 중마황의 (+)-Pseudoephedrine과 (-)-Ephedrine의 동시분석법 개발
- 제목 (타언어)
- Simultaneous Determination of (+)-Pseudoephedrine and (-)-Ephedrine in Ephedra intermedia by HPLC-UV
- 저자
- 정비랑; 윤유식; 신순식; 권용수; 양희정
- 발행일
- 2017
- 유형
- Article
- 저널명
- 생약학회지
- 권
- 48
- 호
- 1
- 페이지
- 93 ~ 96
- 언어
- CHI
- 출판사
- Korean Society of Pharmacognosy
- 발행국가
- 대한민국
- 분량
- 4 페이지
- ISSN
- P 0253-3073