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A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins
- Choi, Y.J.;
- Chae, S.;
- Kim, J.H.;
- Park, J.Y.;
- Lee, S.-H.
Citations
SCOPUS
0초록
In this paper, we introduce a microfluidic system to analyze the effect of oligomeric assemblies of amyloid beta on neurons quantitatively with well-organized in vivo-like microenvironment. By generating extremely slow flow rate and gradient of oligomeric assemblies of amyloid beta, our microfluidic platform simulates the regulated intramembrane proteolysis (RIP), a convergence physiological mechanism.
키워드
Microfluidic gradient chip; Oligomeric assemblies of amyloid beta; Glycoproteins; Microfluidics; Oligomers; Amyloid betas; Culture systems; Intramembrane proteolysis; Micro fluidic system; Microenvironments; Microfluidic platforms; Neurotoxicity; Physiological mechanisms; Proteins
- 제목
- A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins
- 저자
- Choi, Y.J.; Chae, S.; Kim, J.H.; Park, J.Y.; Lee, S.-H.
- 발행일
- 2012-11
- 유형
- Conference Paper
- 저널명
- Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
- 페이지
- 902 ~ 904
- 언어
- ENG
- 출판사
- Chemical and Biological Microsystems Society
- 분량
- 3 페이지
- ISSN
- P 0000-0000