PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OVARY GRANULOSA CELL TUMORS CONTAINING GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITOR AS ACTIVE INGREDIENT, AND FUNCTIONAL HEALTH FOOD COMPOSITION

초록

The present invention relates to a pharmaceutical composition for preventing or treating ovary granulosa cell tumors containing, as an active ingredient, one selected from the group consisting of a compound represented by chemical formula 1, a pharmaceutically acceptable salt of the compound represented by chemical formula 1, a compound represented by chemical formula 2, and a pharmaceutically acceptable salt of the compound represented by chemical formula 2, or a functional health food composition. The composition according to the present invention inhibits glycogen synthase kinase-3 beta (GSK3beta) and thus has an effect of inhibiting a phosphorylation of a serine, which is the 33rd amino acid of the forkhead box L2 (FOXL2) protein, by containing, as an active ingredient, one selected from the group consisting of the compound represented by chemical formula 1, the pharmaceutically acceptable salt of the compound represented by chemical formula 1, the compound represented by chemical formula 2, and the pharmaceutically acceptable salt of the compound represented by chemical formula 2, so that the composition can be useful as a composition for preventing or treating ovary granulosa cell tumors. Further, the composition according to the present invention is expected to be also useful as a functional health food composition.