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Discovery of novel FGFR4 inhibitors through a build-up fragment strategy
- Kim, Jihyung;
- Im, Chang Gyun;
- Oh, Kyujin;
- Lee, Ji Min;
- Al-Rubaye, Fatimah;
- ... Min, Kyung Hoon
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1초록
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. FGFR4 has been implicated in HCC progression, making it a promising therapeutic target. We introduce an approach for identifying novel FGFR4 inhibitors by sequentially adding fragments to a common warhead unit. This strategy resulted in the discovery of a potent inhibitor, 4c, with an IC50 of 33 nM and high selectivity among members of the FGFR family. Although further optimisation is required, our approach demonstrated the potential for discovering potent FGFR4 inhibitors for HCC treatment, and provides a useful method for obtaining hit compounds from small fragments.
키워드
FGFR4; fragment; hit identification; kinase inhibitor; small molecule; SORAFENIB
- 제목
- Discovery of novel FGFR4 inhibitors through a build-up fragment strategy
- 저자
- Kim, Jihyung; Im, Chang Gyun; Oh, Kyujin; Lee, Ji Min; Al-Rubaye, Fatimah; Min, Kyung Hoon
- 발행일
- 2024-12
- 유형
- Article
- 권
- 39
- 호
- 1