ScholarWorks@중앙대학교

초록

Objective Impact of statin use on progression and survival in Parkinson’s disease (PD) remains unclear; limited evidence in Asian populations. This study aims to assess association between statin prescription, cumulative dosage, and all-cause mortality in PD. Methods This retrospective cohort study was conducted using a population-based sample from the Korean National Health Insurance Service (KNHIS) claims database. The study included 3,152 adults diagnosed with PD, with history of statin use and cumulative dose information obtained from claims records. Data were collected from the KNHIS database, and all eligible participants were followed longitudinally to ascertain all-cause mortality. The primary outcome was all-cause mortality, and the exposures were statin use (yes or no) and cumulative dose. The analysis was conducted using Cox proportional hazards regression, adjusted for relevant covariates. Results Statin use associated with lower all-cause mortality risk (hazard ratio [HR], 0.600; 95% CI, 0.521–0.691). Among statin users, higher cumulative statin dose linked to further mortality reduction (HR, 0.800; 95% CI, 0.761–0.842). Conclusions Statin use and higher cumulative exposure were associated with reduced all-cause mortality in patients with Parkinson’s disease, and these findings suggest a potential survival benefit and warrant further investigation in diverse populations.

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