Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

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9

초록

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs ( NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.

키워드

Cholangiopancreatography; endoscopic retrograde; Pancreatitis; Anti-inflammatory agents; non-steroidal; HIGH-RISK PATIENTS; ERCP PANCREATITIS; RANDOMIZED-TRIAL; SELECTIVE-INHIBITION; DOUBLE-BLIND; INDOMETHACIN; DICLOFENAC; SEVERITY; METAANALYSIS; INTERLEUKIN-1-BETA
제목
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
저자
Park, Tae Young; Oh, Hyoung-Chul; Fogel, Evan L.; Lehman, Glen A.
DOI
10.3904/kjim.2020.069
발행일
2020-05
유형
Review
저널명
The Korean Journal of Internal Medicine
권
35
호
3
페이지
535 ~ 543

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