Long-term Reliability of Diurnal Intraocular Pressure Patterns in Healthy Asians

초록

Purpose: To determine the long-term repeatability of diurnal intraocular pressure (IOP) patterns in healthy Asiansubjects without glaucoma. Methods: Twenty-three eyes in 23 healthy Asian subjects without glaucoma underwent diurnal IOP measurementsusing Goldmann applanation tonometry every 2 hours from 9 AM to 11 PM during two visits that were 8weeks apart. To validate repeatability between visits, we calculated intra-class correlation coefficients (ICCs)mean IOP, peak IOP, minimum IOP, and IOP fluctuation at each time point and expressed the results as thedifference between peak IOP and minimum IOP or as the standard deviation of all diurnal IOP values in thediurnal IOP curve. Results: IOP repeatability was excellent at all time points, with ICCs ranging from 0.812 to 0.946 (p < 0.001). The 9 AM IOP showed the best repeatability between visits (ICCs, 0.946). Repeatability of mean IOP, peakIOP, and minimum IOP was also excellent (ICCs ranging from 0.899 to 0.929). However, IOP fluctuationsshowed poor repeatability, with an ICC lower than 0.15. Conclusions: Long-term repeatability of diurnal IOP patterns in healthy Asian subjects was excellent. Thesefindings suggest that IOP measurements at standardized times of the day will be useful for assessing the effectivenessof glaucoma therapy.

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