Platinum-Catalyzed Deoxygenation of N-Acyloxyamines

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초록

We report a Pt-catalyzed double deoxygenative transformation of N-acyloxyamines, employing PtCl2 catalyst without external ligand under mild conditions. This method facilitates efficient C-N bond formation and can be used to synthesize a broad spectrum of alkylated secondary and tertiary amines with excellent yields. The adaptability and effectiveness of this approach highlight the potential of platinum catalysis to extend beyond traditional synthetic boundaries.

키워드

platinum; acyloxyamine; deoxygenation; reduction; silane; C-N coupling; REDUCTION; AMIDES; HYDROGENATION; SECONDARY; AMINATION; DOMINO
제목
Platinum-Catalyzed Deoxygenation of N-Acyloxyamines
저자
Ali, Kashif; Cho, Eun Jin
DOI
10.1055/a-2410-2291
발행일
2025-02
유형
Article; Early Access
저널명
Synthesis
권
57
호
4
페이지
732 ~ 739