Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites

  • Shin, Seong-Ah; 
  • Moon, Sun Young; 
  • Kim, Woe-Yeon; 
  • Paek, Seung-Mann; 
  • Park, Hyun Ho; 
  • 외 1명
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62
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83

초록

A variety of malignant cancers affect the global human population. Although a wide variety of approaches to cancer treatment have been studied and used clinically (surgery, radiotherapy, chemotherapy, and immunotherapy), the toxic side effects of cancer therapies have a negative impact on patients and impede progress in conquering cancer. Plant metabolites are emerging as new leads for anti-cancer drug development. This review summarizes these plant metabolites with regard to their structures and the types of cancer against which they show activity, organized by the organ or tissues in which each cancer forms. This information will be helpful for understanding the current state of knowledge of the anti-cancer effects of various plant metabolites against major types of cancer for the further development of novel anti-cancer drugs.

키워드

plant; metabolite; cancer; anti-cancer drug; BREAST-CANCER CELLS; NF-KAPPA-B; GREEN TEA POLYPHENOL; LUNG-CARCINOMA CELLS; PROSTATE-CANCER; BENZYL ISOTHIOCYANATE; IN-VITRO; INHIBITS PROLIFERATION; CYCLE ARREST; ORGANOSULFUR COMPOUNDS
제목
Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites
저자
Shin, Seong-Ah; Moon, Sun Young; Kim, Woe-Yeon; Paek, Seung-Mann; Park, Hyun Ho; Lee, Chang Sup
DOI
10.3390/ijms19092651
발행일
2018-09
유형
Review
저널명
International Journal of Molecular Sciences
권
19
호
9

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