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Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism
- Lee, Hobeom;
- Lee, Ji Yun;
- Suh, Moo Hyun;
- Sim, Sang-Soo;
- Lee, Min-Won;
- 외 1명
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We studied effects of hydrolysable tannins on rat papillary muscle contractions induced by propranolol. The developed force of papillary muscle was measured isometrically with an inductive force transducer. The IC50 values for digallic acid, gallic acid, germin D, praecoxin A and 1-desgalloyl rugosin F were 4.2 x 10(-5) M, 1.3 x 10(-4) M, 1.4 x 10(-4) M, 1.5 x 10(-4) and 1.7 x 10(-4) M, respectively. Incubation with tannins significantly attenuated the propranolol-induced negative inotropic contractile response. These results show that hydrolysable tannins depress muscle contractions and potentiate the activities of beta-adrenergic blocker. (C) 2010 Elsevier B.V. All rights reserved.
키워드
Hydrolysable tannins; Inotropic action; Propranolol-induced negative inotropism; Rat papillary muscle; Isometric contraction; GRAPE SEED PROANTHOCYANIDINS; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; HUMAN CANCER; ACID; RATS; ACTIVATION; EXTRACTS; BIOAVAILABILITY; JAPONICA
- 제목
- Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism
- 저자
- Lee, Hobeom; Lee, Ji Yun; Suh, Moo Hyun; Sim, Sang-Soo; Lee, Min-Won; Kim, Chang Jong
- 발행일
- 2010-10
- 유형
- Article
- 저널명
- Fitoterapia
- 권
- 81
- 호
- 7
- 페이지
- 820 ~ 825