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초록
Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-beta-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
키워드
Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC; NITRIC-OXIDE SYNTHASE; LIQUID-CHROMATOGRAPHY; SALIDROSIDE; EXTRACT; INHIBITION; GLYCOSIDES; TYROSOL; PLANTS; ROSEA
- 제목
- The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
- 저자
- Choe, Kang In; Kwon, Joo Hee; Park, Kwan Hee; Oh, Myeong Hwan; Kim, Manh Heun; Kim, Han Hyuk; Cho, Su Hyun; Chung, Eun Kyung; Ha, Sung Yi; Lee, Min Won
- 발행일
- 2012-10
- 유형
- Article
- 저널명
- Molecules
- 권
- 17
- 호
- 10
- 페이지
- 11484 ~ 11494