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A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment
- Lee, Wonhwa;
- Seo, Junyoung;
- Kwak, Soyoung;
- Park, Eun Ji;
- Na, Dong Hee;
- 외 4명
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39초록
New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
키워드
ferritin; nanoparticles; PC-gla; sepsis; TRAP; ENDOTHELIAL-CELLS; ADHESION MOLECULES; SERUM FERRITIN; NANOPARTICLES; ACTIVATION; EXPRESSION; PATHWAY; ANTICOAGULANT; EPIDEMIOLOGY; PERMEABILITY
- 제목
- A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment
- 저자
- Lee, Wonhwa; Seo, Junyoung; Kwak, Soyoung; Park, Eun Ji; Na, Dong Hee; Kim, Soyoun; Lee, You Mie; Kim, In-San; Bae, Jong-Sup
- 발행일
- 2015-11
- 유형
- Article
- 권
- 27
- 호
- 42
- 페이지
- 6637 ~ 6643
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 독일
- 분량
- 7 페이지
- ISSN
- E 1521-4095
P 0935-9648