상세 보기
Anti-inflammatory effect of germanium-concentrated yeast against paw oedema is related to the inhibition of arachidonic acid release and prostaglandin E2 production in RBL 2H3 cells
- Lee, J.H.;
- Kim, K.W.;
- Yoon, M.Y.;
- Lee, J.Y.;
- Kim, C.J.;
- 외 1명
SCOPUS
7초록
To investigate anti-inflammatory activity of organic germanium, we measured the effect of germanium-concentrated yeast on arachidonic acid release, prostaglandin E2 (PGE2) production, histamine release, and intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells, and carrageenan-induced paw oedema in rats. Germanium-concentrated yeast dose-dependently inhibited carrageenan-induced paw oedema, suggesting that germanium-concentrated yeast has anti-inflammatory activity in acute inflammation. Germanium-concentrated yeast significantly inhibited melittin-induced arachidonic acid release and PGE2 production in RBL 2H3 cells. Germanium-concentrated yeast did not affect melittin-induced histamine release and silica-induced intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells. These results suggest that anti-inflammatory activity of germanium-concentrated yeast appears partly to be related to the inhibition of arachidonic acid release and PGE2 production in RBL 2H3 cells. © 2005 Blackwell Publishing Ltd.
키워드
- 제목
- Anti-inflammatory effect of germanium-concentrated yeast against paw oedema is related to the inhibition of arachidonic acid release and prostaglandin E2 production in RBL 2H3 cells
- 저자
- Lee, J.H.; Kim, K.W.; Yoon, M.Y.; Lee, J.Y.; Kim, C.J.; Sim, S.S.
- 발행일
- 2005-10
- 유형
- Article
- 권
- 25
- 호
- 4
- 페이지
- 129 ~ 134
- 언어
- ENG
- 발행국가
- 영국
- 분량
- 6 페이지
- ISSN
- P 1474-8665