ScholarWorks@중앙대학교

초록

Photo-theranostic materials are designed for both diagnostic imaging and therapeutic applications under specific light sources, particularly in translational medicine. While various photo-theranostic materials have been developed for disease treatment, their cooperative effects on biologically abundant species, such as proteins, have rarely been studied in terms of biological activity. In this work, we disclose a photo-theranostic agent (named NBSD-Chol) based on nitrobenzoselenadiazole (NBSD) and cholesterol (Chol), which is activatable in situ through lipoprotein hybridization. NBSD-Chol demonstrates outstanding potential for cancer imaging and photodynamic therapy (PDT) due to its unique properties, including (i) tumor targeting after oral uptake, (ii) tumor visualization under light irradiation for image-guided surgery, (iii) superior PDT effects, and (iv) downgrading hazard ratios (HR) related to clinically critical proteins. Overall, this work contributes to advancing translational medicine by developing innovative treatments for cancer using visible light, ushering in a new era of intraoperative technology and photodynamic fluorescence-guided surgical agents. © 2025 Elsevier Ltd

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