gamma-Cyclodextrin-phenylacetic acid mesh as a drug trap

초록

In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using gamma-cyclodextrin (gamma-CD) conjugated with phenylacetic acid (PA), named gamma-CDP. The resulting gamma-CDP has a microfibrous or microspherical shape and contains drug trap meshlike gamma-CD pores. These gamma-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep gamma-CDP nanocompartments or out of the gamma-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the gamma-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.

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