Contrast Media-Induced Nephropathy in Patients with Unruptured Cerebral Aneurysm After Coiling Endovascular Treatment

초록

BACKGROUND: The endovascular coiling procedure to treat cerebral aneurysms using contrast media has become more popular. However, studies of the incidence of, and risk factors for, contrast media-induced nephropathy (CIN) after coiling procedures have been limited. Thus, we evaluated the incidence and risk factors for CIN in patients who had undergone cerebral aneurysmal coiling procedures. METHODS: We retrospectively reviewed the electric medical records of 380 patients who had undergone cerebral aneurysmal coiling treatment under general anesthesia. CIN was defined as an absolute increase in serum creatinine (>= 0.5 mg/dL) or a relative increase (>= 25%) in the baseline serum creatinine value at 48-72 hours after exposure to a contrast agent. RESULTS: Elective cerebral aneurysmal coiling procedures were performed in 230 patients. Of the 230 patients, CIN developed in 13 (5.6%). The presence of diabetes mellitus (30.8% vs. 9.7%; P = 0.040) and patient age > 75 years (30.8% vs. 6.5%; P = 0.012) were risk factors for CIN. CONCLUSIONS: Our study has demonstrated that the incidence of CIN in patients undergoing elective cerebral aneurysmal coiling procedures is similar to 6.0%. We also identified underlying diabetes mellitus and advanced age (>= 75 years) as potential risk factors.

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