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Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition
- Goo, Y.T.;
- Jin, C.H.;
- Kim, M.S.;
- Han, S.B.;
- Choi, Y.W.
Citations
SCOPUS
5초록
Lansoprazole (LSP)-loaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC.
키워드
Acidic stability; Cochleate; Dicetyl phosphate; Dimyristoyl phosphatidylcholine; Lansoprazole
- 제목
- Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition
- 저자
- Goo, Y.T.; Jin, C.H.; Kim, M.S.; Han, S.B.; Choi, Y.W.
- 발행일
- 2021-10
- 유형
- Article in Press
- 권
- 42
- 호
- 10
- 페이지
- 1281 ~ 1284
- 언어
- ENG
- 출판사
- John Wiley and Sons Inc
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1229-5949
P 0253-2964