상세 보기
A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water
- Byeon H.-J.;
- Jung K.-H.;
- Moon G.-S.;
- Moon S.-K.;
- Lee H.-Y.
Citations
WEB OF SCIENCE
14Citations
SCOPUS
20초록
A facile and efficient synthesis of tetrahydro-β-carbolines (tryptolines) in one step from tryptamine and aldehydes, in an environmentally friendly water solvent, has been investigated. This convenient and clean synthesis of various tryptolines was facilitated by l-tartaric acid, a natural compound, to obtain the desired products as clear crystals. Among the four crystalline products, the most substituted tryptoline 2 showed the best inhibitory activity against EJ cells and the least cytotoxicity, with an LC50 value of 1.49 mg/mL, against brine shrimp larvae. © 2020, The Author(s).
키워드
CATALYSIS
- 제목
- A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water
- 저자
- Byeon H.-J.; Jung K.-H.; Moon G.-S.; Moon S.-K.; Lee H.-Y.
- 발행일
- 2020-01
- 유형
- Article
- 권
- 10
- 호
- 1
- 언어
- ENG
- 출판사
- Nature Research
- 발행국가
- 영국
- ISSN
- P 2045-2322