Nickel-catalyzed cross-coupling of bromophenols with Grignard reagents in the solid phase synthesis

초록

Polymer-bound substituted bromophenols were found to readily undergo a Ni(0)-catalyzed cross-coupling reaction with Grignard reagents to give a variety of substituted phenols and hydroquinones, after cleavage from the support, in moderate to high yields. The requisite bromophenol derivatives, which were prepared from the corrresponding phenols and hydroquinone using BTMA Br-3 or TBA Br-3, were attached to the solid support by the Mitsunobu reaction.

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