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The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
- Lee, Kyoung-Tae;
- Jung, Tae Woo;
- Lee, Hak-Ju;
- Kim, Seul-Gi;
- Shin, Yu-Su;
- 외 1명
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102초록
Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.
키워드
Panax ginseng; Rb2; AMPK; SHP; H4IIE cells; ENDOPLASMIC-RETICULUM STRESS; PROTEIN-KINASE; PANAX-GINSENG; GLUCOSE-UPTAKE; LIPID-METABOLISM; LIVER; CELLS; GLUCONEOGENESIS; HEPATOCYTES; APOPTOSIS
- 제목
- The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
- 저자
- Lee, Kyoung-Tae; Jung, Tae Woo; Lee, Hak-Ju; Kim, Seul-Gi; Shin, Yu-Su; Whang, Wan-Kyunn
- 발행일
- 2011-07
- 유형
- Article
- 권
- 34
- 호
- 7
- 페이지
- 1201 ~ 1208
- 언어
- ENG
- 출판사
- PHARMACEUTICAL SOC KOREA
- 발행국가
- 대한민국
- 분량
- 8 페이지
- ISSN
- E 1976-3786
P 0253-6269