ScholarWorks@중앙대학교

초록

A nickel(II)-catalyzed reductive amination of carboxylic acids with amines is described, employing phenylsilane as the reductant. The reaction proceeds via an iminium ion/imine intermediate and does not require prior carboxylic acid activation. A comprehensive evaluation of ligands identified bulky trialkyl monophosphines as optimal, with tricyclohexylphosphine providing the highest yield. This ligand-controlled protocol provides direct access to diverse secondary and tertiary amines from readily available carboxylic acids, illustrating a practical approach to C-N bond formation.

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