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Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
- Han, Ga-Dug;
- Kim, Jae-Won;
- Noh, Seung-Hyun;
- Kim, Shin-Woong;
- Jang, Eui-Chan;
- ... Kim, Mi-Kyung;
- 외 4명
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16Citations
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19초록
Post-operative adhesion is a very serious complication in the clinical field, frequently occurring after surgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent. © 2018 The Korean Society of Industrial and Engineering Chemistry
키워드
Furfuryl hyaluronic acid; Ibuprofen; Photo-immobilization; Riboflavin; Anti-adhesion; Anti-inflammation; ADHESION FORMATION; TENDON REPAIR; PREVENTION; CHITOSAN; IBUPROFEN; HYDROGEL; MEMBRANES; RELEASE
- 제목
- Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
- 저자
- Han, Ga-Dug; Kim, Jae-Won; Noh, Seung-Hyun; Kim, Shin-Woong; Jang, Eui-Chan; Nah, Jae-Woon; Lee, Young-Gi; Kim, Mi-Kyung; Ito, Yoshihiro; Son, Tae-Il
- 발행일
- 2019-02
- 유형
- Article in Press
- 권
- 70
- 페이지
- 204 ~ 210
- 언어
- ENG
- 출판사
- Korean Society of Industrial Engineering Chemistry
- 발행국가
- 미국
- 분량
- 7 페이지
- ISSN
- E 1876-794X
P 1226-086X