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In vitro bactericidal and anticancer activity of new metabolite, ARK42, isolated from Aspergillus repens K42
- Park, Je Won;
- Song, Beom Seok;
- Ryu, DoJin;
- Lee, Chan;
- Kim, Young Bae
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3초록
A novel antibacterial metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 mug/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 mug/ml. Furthermore, anticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC50 of 10 and 1 mug/ml, respectively.
키워드
Aspergillus repens; bactericidal activity; anticancer activity; GLAUCUS GROUP; ANTHRAQUINONES; MICROORGANISMS; IDENTIFICATION; MUTAGENICITY; BACTERIOCIN; INHIBITION; PRODUCTS
- 제목
- In vitro bactericidal and anticancer activity of new metabolite, ARK42, isolated from Aspergillus repens K42
- 저자
- Park, Je Won; Song, Beom Seok; Ryu, DoJin; Lee, Chan; Kim, Young Bae
- 발행일
- 2002-12
- 유형
- Article
- 권
- 12
- 호
- 6
- 페이지
- 1017 ~ 1021
- 언어
- ENG
- 출판사
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- 발행국가
- 대한민국
- 분량
- 5 페이지
- ISSN
- E 1738-8872
P 1017-7825