The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis

Baek, Jihae; Lee, Heeyoung; Hwang, Kwang Woo; Kim, Eunyoung; Min, Hyeyoung

doi:10.1016/j.compbiomed.2014.11.019

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The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis

Baek, Jihae;
Lee, Heeyoung;
Hwang, Kwang Woo;
Kim, Eunyoung;
Min, Hyeyoung

Citations

WEB OF SCIENCE

5

Citations

SCOPUS

8

초록

Objective: To determine the relationship between CD28 polymorphisms, rs3116496, and cancer. Design: Meta-analysis. Methods: PubMed, EMBASE, Web of Science, and Cochrane library databases were searched to identify studies reporting the association between CD28 polymorphism and cancer. Two authors selected identified studies, extracted, and analyzed the data independently. Results: Individuals carrying a T allele (TT homozygotes and TT+TC heterozygotes) at rs3116496 had a lower incidence of cancer than carriers of a C allele. Subgroup analysis showed that this association held true for Asians, but not Europeans. Conclusion: CD28 polymorphism, rs3116496, contributes to cancer susceptibility in the case of multiple cancers.

키워드

CD28; Polymorphism; Genetic variants; Cancer; Meta-analysis; T-CELL-ACTIVATION; ICOS GENE POLYMORPHISMS; B7 FAMILY; CYCLE PROGRESSION; PUBLICATION BIAS; LUNG-CANCER; CTLA-4; COSTIMULATION; PROLIFERATION; LYMPHOCYTES

제목: The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis

저자: Baek, Jihae; Lee, Heeyoung; Hwang, Kwang Woo; Kim, Eunyoung; Min, Hyeyoung

DOI: 10.1016/j.compbiomed.2014.11.019

발행일: 2015-06

유형: Article

저널명: Computers in Biology and Medicine

권: 61

페이지: 172 ~ 177

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 6 페이지

ISSN: E 1879-0534
P 0010-4825