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Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
- Deng, Zheo-fen;
- Bakunina, Irina;
- Yu, Hua;
- Han, Jaehong;
- Dömling, Alexander;
- 외 2명
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WEB OF SCIENCE
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5초록
Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR. Copyright © 2022 Deng, Bakunina, Yu, Han, Dömling, Ferreira and Zhang.
키워드
cancer; chemotherapy; diterpenoids; multidrug resistance; natural products; P-GLYCOPROTEIN MODULATORS; EUPHORBIA FACTOR L1; PSEUDOLARIC-ACID-B; JATROPHANE DITERPENOIDS; TAXUS-CUSPIDATA; MOUSE LYMPHOMA; MACROCYCLIC DITERPENES; BIOLOGICAL EVALUATION; POTENT MODULATORS; CANCER-CELLS
- 제목
- Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
- 저자
- Deng, Zheo-fen; Bakunina, Irina; Yu, Hua; Han, Jaehong; Dömling, Alexander; Ferreira, Maria.-Jose U; Zhang, Jian-ye
- 발행일
- 2022-03
- 유형
- Review
- 권
- 13
- 언어
- ENG
- 출판사
- Frontiers Media S.A.
- 발행국가
- 스위스
- ISSN
- E 1663-9812
P 1663-9812